K9 Select HMR Multi-Formula Peanut Butter Formula Dog Hormone Supplement is specifically designed for dogs affected by Cushing’s Disease. Providing hormone and liver support, along with melatonin to assist in promoting normal thirst and urination, this supplement can help make your doggy’s life easier. The first active ingredient is HMR lignans—sourced from Norwegian spruce tree knots. The second active ingredient is melatonin. Supplementing with melatonin can be highly beneficial, as melatonin is a well-known antioxidant that can help regulate hormones and reduce stress and anxiety. The third active ingredient is milk thistle, standardized to 80% Silymarin. An antioxidant, milk thistle may contribute to a healthy liver in dogs. And since Cushing's Disease can cause liver problems, these supplements are a great option to support a healthy liver and a healthy dog!